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Jeremy W Tomlinson Selected Research

11-beta-Hydroxysteroid Dehydrogenase Type 1

12/2010Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation?
9/201011beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
11/200911beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
1/2009Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
10/2008Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.
10/2008Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.
6/2008Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss.
9/2007Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
2/2007Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
12/2005Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
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Jeremy W Tomlinson Research Topics

Disease

28Insulin Resistance
02/2022 - 06/2004
22Obesity
02/2022 - 11/2002
15Non-alcoholic Fatty Liver Disease
06/2022 - 07/2009
10Cushing Syndrome
04/2017 - 01/2002
9Type 2 Diabetes Mellitus (MODY)
02/2022 - 12/2005
9Metabolic Syndrome (Dysmetabolic Syndrome X)
11/2018 - 10/2004
8Weight Loss (Weight Reduction)
08/2022 - 06/2004
8Abdominal Obesity
07/2012 - 04/2002
7Overweight
02/2022 - 07/2009
7Inflammation (Inflammations)
01/2021 - 01/2010
6Fibrosis (Cirrhosis)
01/2020 - 02/2015
5Hepatocellular Carcinoma (Hepatoma)
06/2022 - 05/2014
5Hypertension (High Blood Pressure)
04/2017 - 06/2003
5Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
01/2017 - 08/2003
4Body Weight (Weight, Body)
02/2022 - 07/2012
4Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)
01/2021 - 12/2010
4Cortisone reductase deficiency
10/2008 - 08/2003
3Neoplasms (Cancer)
01/2022 - 01/2013
3Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal)
04/2021 - 01/2017
3Adrenal Insufficiency (Adrenal Gland Hypofunction)
11/2019 - 01/2006
3Alcoholic Fatty Liver
02/2016 - 11/2013
3Fatty Liver
02/2016 - 12/2013
3Metabolic Diseases (Metabolic Disease)
01/2016 - 10/2014
3Glucose Intolerance
06/2014 - 10/2008
3Muscular Diseases (Myopathy)
06/2014 - 01/2002
2Osteoporosis
04/2017 - 10/2004
2Hyperplasia
04/2017 - 02/2007
2Diabetes Mellitus
10/2014 - 09/2007
2Hyperinsulinism (Hyperinsulinemia)
06/2014 - 06/2008
2Atherosclerosis
09/2010 - 12/2007
2Pituitary ACTH Hypersecretion
06/2010 - 01/2002
1Hypoxia (Hypoxemia)
06/2022
1Hypertriglyceridemia
01/2022
1Disease Progression
01/2022
1Cardiovascular Diseases (Cardiovascular Disease)
01/2022
1Prostatic Diseases
01/2021
1Disorders of Sex Development (Intersexuality)
01/2021
1Sarcopenia
01/2021
1Addison Disease (Addison's Disease)
01/2020
1Alstrom Syndrome
11/2018
1Idiopathic Pulmonary Fibrosis
11/2018
1Triple X syndrome
11/2018
1Adenoma (Adenomas)
04/2017

Drug/Important Bio-Agent (IBA)

31GlucocorticoidsIBA
08/2022 - 01/2002
20Hydrocortisone (Cortisol)FDA LinkGeneric
04/2017 - 01/2002
1711-beta-Hydroxysteroid Dehydrogenase Type 1IBA
12/2010 - 01/2002
14Glucose (Dextrose)FDA LinkGeneric
06/2022 - 09/2007
14LipidsIBA
06/2022 - 12/2007
13AndrogensIBA
01/2021 - 08/2003
11Insulin (Novolin)FDA Link
02/2022 - 11/2007
11EnzymesIBA
01/2020 - 01/2002
8Oxidoreductases (Dehydrogenase)IBA
01/2020 - 10/2004
7Triglycerides (Triacylglycerol)IBA
02/2022 - 07/2012
7SteroidsIBA
01/2020 - 10/2008
7CortisoneFDA Link
01/2012 - 01/2002
5Adrenocorticotropic Hormone (ACTH)FDA Link
06/2010 - 01/2002
4IsotopesIBA
06/2022 - 01/2019
4Hormones (Hormone)IBA
04/2021 - 06/2010
4Biomarkers (Surrogate Marker)IBA
01/2021 - 10/2008
4galactose-6-phosphate dehydrogenaseIBA
10/2008 - 08/2003
3Fatty Acids (Saturated Fatty Acids)IBA
06/2022 - 02/2016
3Adrenal Cortex Hormones (Corticosteroids)IBA
04/2021 - 01/2002
3MineralocorticoidsIBA
01/2020 - 10/2014
3Glucagon-Like Peptide 1 (GLP 1)IBA
02/2016 - 11/2013
3LiraglutideFDA Link
02/2016 - 11/2013
3Insulin-Like Growth Factor I (IGF-1)IBA
07/2015 - 05/2003
2Pharmaceutical PreparationsIBA
01/2022 - 01/2021
2Testosterone (Sustanon)FDA Link
01/2021 - 01/2019
22- (1- (5- (cyclohexylcarbamoyl)- 6- propylsulfanylpyridin- 2- yl)- 3- piperidyl)acetic acidIBA
01/2021 - 01/2020
2Androstenedione (4 Androstene 3,17 dione)IBA
01/2019 - 03/2014
2Glycerol (Glycerine)FDA LinkGeneric
01/2019 - 06/2008
2FatsIBA
01/2016 - 05/2014
2FructoseIBA
01/2016 - 05/2014
2Dexamethasone (Maxidex)FDA LinkGeneric
01/2011 - 01/2002
1Sex Hormone-Binding GlobulinIBA
02/2022
1HDL CholesterolIBA
02/2022
1Metformin (Glucophage)FDA LinkGeneric
02/2022
1Immunoglobulin G (IgG)IBA
01/2021
1Biological ProductsIBA
01/2021
1Polysaccharides (Glycans)IBA
01/2021
1RNA (Ribonucleic Acid)IBA
01/2021
1LeptinIBA
01/2021
1Sodium-Glucose Transporter 2 InhibitorsIBA
06/2020
1Sodium-Glucose Transport ProteinsIBA
06/2020
1ReninIBA
01/2020
1SaltsIBA
01/2020
1theasinensin AIBA
11/2019
1GlycogenIBA
10/2019
1Messenger RNA (mRNA)IBA
10/2019
1CarbohydratesIBA
01/2019
1Nonesterified Fatty Acids (NEFA)IBA
01/2019
1Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
01/2019
1setogepramIBA
11/2018
1Cytochrome P-450 CYP11B2 (CYP11B2)IBA
04/2017
1AldosteroneIBA
04/2017

Therapy/Procedure

8Therapeutics
01/2022 - 01/2013
3Liver Transplantation
06/2020 - 06/2015
2Bariatric Surgery
08/2022 - 01/2021
2Drug Therapy (Chemotherapy)
06/2022 - 02/2022
2Caloric Restriction
12/2019 - 06/2004